Because you have utilized “Linear Up and Log Down method” for AUC calculation whereas I have used “Linear Trapezoidal Linear Interpolation” method. Thanks for guiding me how connect BE object to NCA.īy using this technique provided by you, I got the same results as compared to yours, except AUC values. But after re-executing the total workflow, it displays as normal.įinally, As far as that unusual thing in my workflow is concern, actually I had tried my best to connect BE tool directly to NCA object but couldn’t find the way to add period and sequence column in Final parameteer pivoted sheet (in NCA output). In that, NCA and Bioequivalence both objects are red highlighted in new version. The attachment you have provided is accessible after changing its extension. Is it new feature of WinNonlin 6.2 (to Eexecute workflow)? Because in last version I couldn’t find it any
Same way you mentioned, if I re-execute the workflow of earlier studies in new version then also result doesn’t get highlighted. That time it doesn’t show red highlighted results. from inputting data of concentration into data folder to till BE object) in version 6.2. įrom your first reply, where you were asking about repeat calculation, I meant if I completely repeat the study (i.e. I've attached an example of the suggestion - Can you out of interest open this 6.1 project and tell me what you see in 6.2 There is one unusual thing in your workflow I noted why have you linked the BE object to a copy of the Final Parameters file in the data folder - this means that the data is now static whereas the 'expected way to build that workflow would be to link the NCA final parameters sheetdirectly to the BE tool I did try to look at the project you attached in 6.1 but it was saved in 6.2.
For NCA I can't think of anything that would cause that, however in a Phoenix model there are known enhancements that are highlighted to the user when opening a 6.1 project in 6.2. If so then you are doing the correct process.Įssentially Phoenix is suggesting there maybe a change in settings between 6.1 and 6.2 and is indicating you should re-execute the results. re-executed the existing red NCA object?. Tushar, when you say 'repeat' the analysis in 6.2 do you mean you 'refreshed' i.e.
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